Carotid intima media thickness and white matter hyperintensity volume among midlife women

(A) Scatterplot of raw relationship between IMT (log) and WMHV (log) at the MsBrain visit by APOE ɛ4 status (orange = APOE ɛ4 positive, blue = APOE ɛ4 negative); (B) MRI scans of white matter hyperintensity volumes in representative women with low, medium, and high IMT by APOE ɛ4 status. Notes: WMHV values normalized by ICV; IMT represents mean IMT over eight locations of carotid artery; WMHV expressed as mm3/Intracranial volume (in mm3). APOE, apolipoprotein E; ICV, intracranial volume; IMT, intima media t

Dr. Rebecca Thurston's research found that greater carotid intima media thickness (IMT) is associated with greater brain white matter hyperintensities (WMH) among older individuals, yet few studies consider these associations at midlife. Even fewer studies focus on women. The neuropathological hallmarks of Alzheimer's disease and related dementias accumulate at midlife. For women, midlife includes the menopause transition.

Read about Dr. Thurston's findings here: https://pubmed.ncbi.nlm.nih.gov/36722746/